November 2018
Vol 3, Issue 29

About The Cover

Cover image expansion

ONLINE COVER Double Feature. This month's cover illustration is an artist's depiction of changes in intratumoral CD8+ T cell function elicited by combination cancer immunotherapy. Wang et al. report that treatment with both agonist anti-GITR and blocking anti-PD-1 antibodies (only affecting the right half of the T cell) triggers transcriptional pathways that lead to enhanced cellular activation (orange cell membrane) and increased cytokine production (dark blue ovals emerging from cell surface). Synergistic activation of the in vivo CD8+ T cell response is associated with robust tumor elimination (with tan cancer cells infiltrating only alongside the untreated left half of the T cell). [CREDIT: RACHEL URKOWITZ]