Research ArticleCANCER IMMUNOLOGY
The immune system profoundly restricts intratumor genetic heterogeneity
- Idan Milo1,2,
- Marie Bedora-Faure3,
- Zacarias Garcia1,2,
- Ronan Thibaut1,2,4,
- Leïla Périé5,6,
- Guy Shakhar7,
- Ludovic Deriano3 and
- Philippe Bousso1,2,*
- 1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
- 2INSERM U1223, 75015 Paris, France.
- 3Genome Integrity, Immunity and Cancer Unit, Department of Immunology, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
- 4University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, rue du Dr Roux, 75015 Paris, France.
- 5Institut Curie, PSL Research University, CNRS UMR168, 11 rue Pierre et Marie Curie, 75005 Paris, France.
- 6Sorbonne Universités, UPMC University Paris 06, 4 place Jussieu, 75005 Paris, France.
- 7Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
- ↵*Corresponding author. Email: philippe.bousso{at}pasteur.fr
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Science Immunology 23 Nov 2018:
Vol. 3, Issue 29, eaat1435
DOI: 10.1126/sciimmunol.aat1435
