Research ArticleCANCER IMMUNOLOGY
The immune system profoundly restricts intratumor genetic heterogeneity
- View ORCID ProfileIdan Milo1,2,
- Marie Bedora-Faure3,
- Zacarias Garcia1,2,
- Ronan Thibaut1,2,4,
- Leïla Périé5,6,
- View ORCID ProfileGuy Shakhar7,
- View ORCID ProfileLudovic Deriano3 and
- View ORCID ProfilePhilippe Bousso1,2,*
- 1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
- 2INSERM U1223, 75015 Paris, France.
- 3Genome Integrity, Immunity and Cancer Unit, Department of Immunology, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
- 4University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, rue du Dr Roux, 75015 Paris, France.
- 5Institut Curie, PSL Research University, CNRS UMR168, 11 rue Pierre et Marie Curie, 75005 Paris, France.
- 6Sorbonne Universités, UPMC University Paris 06, 4 place Jussieu, 75005 Paris, France.
- 7Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
- ↵*Corresponding author. Email: philippe.bousso{at}pasteur.fr
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Science Immunology 23 Nov 2018:
Vol. 3, Issue 29, eaat1435
DOI: 10.1126/sciimmunol.aat1435
Vol. 3, Issue 29, eaat1435
DOI: 10.1126/sciimmunol.aat1435
Idan Milo
1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
2INSERM U1223, 75015 Paris, France.
Marie Bedora-Faure
3Genome Integrity, Immunity and Cancer Unit, Department of Immunology, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
Zacarias Garcia
1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
2INSERM U1223, 75015 Paris, France.
Ronan Thibaut
1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
2INSERM U1223, 75015 Paris, France.
4University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, rue du Dr Roux, 75015 Paris, France.
Leïla Périé
5Institut Curie, PSL Research University, CNRS UMR168, 11 rue Pierre et Marie Curie, 75005 Paris, France.
6Sorbonne Universités, UPMC University Paris 06, 4 place Jussieu, 75005 Paris, France.
Guy Shakhar
7Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Ludovic Deriano
3Genome Integrity, Immunity and Cancer Unit, Department of Immunology, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
Philippe Bousso
1Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.
2INSERM U1223, 75015 Paris, France.
