Single-cell transcriptional analysis reveals ILC-like cells in zebrafish

Pedro P. Hernández; Paulina M. Strzelecka; Emmanouil I. Athanasiadis; Dominic Hall; Ana F. Robalo; Catherine M. Collins; Pierre Boudinot; Jean-Pierre Levraud; Ana Cvejic

doi:10.1126/sciimmunol.aau5265

Research ArticleINNATE LYMPHOID CELLS

Single-cell transcriptional analysis reveals ILC-like cells in zebrafish

View ORCID ProfilePedro P. Hernández ¹,²,*,†,
View ORCID ProfilePaulina M. Strzelecka³,⁴,⁵,*,
View ORCID ProfileEmmanouil I. Athanasiadis³,⁴,⁵,*,
View ORCID ProfileDominic Hall⁵,
Ana F. Robalo¹,²,
Catherine M. Collins⁶,
View ORCID ProfilePierre Boudinot⁷,
View ORCID ProfileJean-Pierre Levraud ¹,²,*,† and
View ORCID ProfileAna Cvejic ³,⁴,⁵,*,†

¹Macrophages et Développement de l'Immunité, Institut Pasteur, Paris, France.
²Centre National de la Recherche Scientifique, UMR3738, Paris, France.
³Department of Haematology, University of Cambridge, Cambridge, UK.
⁴Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
⁵Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.
⁶Marine Scotland Science, Marine Laboratory, Aberdeen, UK.
⁷Institut National de la Recherche Agronomique, Virologie et Immunologie Moléculaire, Jouy-en-Josas, France.

↵†Corresponding author. Email: as889{at}cam.ac.uk (A.C.); jean-pierre.levraud{at}pasteur.fr (J.-P.L.); pedro.hernandez-cerda{at}pasteur.fr (P.P.H.)

↵* These authors contributed equally to this work.

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Science Immunology 16 Nov 2018:
Vol. 3, Issue 29, eaau5265
DOI: 10.1126/sciimmunol.aau5265

Pedro P. Hernández

1Macrophages et Développement de l'Immunité, Institut Pasteur, Paris, France.

2Centre National de la Recherche Scientifique, UMR3738, Paris, France.

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ORCID record for Pedro P. Hernández
For correspondence: as889@cam.ac.uk jean-pierre.levraud@pasteur.fr pedro.hernandez-cerda@pasteur.fr

Paulina M. Strzelecka

3Department of Haematology, University of Cambridge, Cambridge, UK.

4Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

5Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

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Emmanouil I. Athanasiadis

3Department of Haematology, University of Cambridge, Cambridge, UK.

4Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

5Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

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Dominic Hall

5Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

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Ana F. Robalo

1Macrophages et Développement de l'Immunité, Institut Pasteur, Paris, France.

2Centre National de la Recherche Scientifique, UMR3738, Paris, France.

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Catherine M. Collins

6Marine Scotland Science, Marine Laboratory, Aberdeen, UK.

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Pierre Boudinot

7Institut National de la Recherche Agronomique, Virologie et Immunologie Moléculaire, Jouy-en-Josas, France.

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Jean-Pierre Levraud

1Macrophages et Développement de l'Immunité, Institut Pasteur, Paris, France.

2Centre National de la Recherche Scientifique, UMR3738, Paris, France.

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ORCID record for Jean-Pierre Levraud
For correspondence: as889@cam.ac.uk jean-pierre.levraud@pasteur.fr pedro.hernandez-cerda@pasteur.fr

Ana Cvejic

3Department of Haematology, University of Cambridge, Cambridge, UK.

4Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

5Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

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ORCID record for Ana Cvejic
For correspondence: as889@cam.ac.uk jean-pierre.levraud@pasteur.fr pedro.hernandez-cerda@pasteur.fr

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Single-cell transcriptional analysis reveals ILC-like cells in zebrafish

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