Research ArticleB CELLS

Intrinsic properties of human germinal center B cells set antigen affinity thresholds

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Science Immunology  30 Nov 2018:
Vol. 3, Issue 29, eaau6598
DOI: 10.1126/sciimmunol.aau6598

Article Information

vol. 3 no. 29

Published By: 
  • Received July 3, 2018
  • Accepted October 26, 2018

Author Information

  1. Kihyuck Kwak1,
  2. Nicolas Quizon1,
  3. Haewon Sohn1,
  4. Avva Saniee1,
  5. Javier Manzella-Lapeira1,
  6. Prasida Holla1,
  7. Joseph Brzostowski1,
  8. Jinghua Lu1,
  9. HengYi Xie2,
  10. Chenguang Xu2,
  11. Katelyn M. Spillane3,4,5,
  12. Pavel Tolar4,5 and
  13. Susan K. Pierce1,*
  1. 1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
  2. 2MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing, China.
  3. 3Department of Physics, King’s College London, London WC2R 2LS, UK.
  4. 4Immune Receptor Activation Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  5. 5Division of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK.
  1. *Corresponding author. Email: spierce{at}


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