December 2018
Vol 3, Issue 30
  • Focus

  • Research Articles

    • Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

      Human IFN-γ–dependent immunity to mycobacteria is less compromised in IL-12Rβ2 or IL-23R deficiency than IL-12Rβ1 deficiency.

    • Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

      Homozygosity for the P1104A missense variant of the TYK2 Janus kinase is common monogenic etiology of primary tuberculosis.

    • The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells

      Skin-resident Tregs suppress the TH17 pathway through a cell-intrinsic mechanism dependent on both CD27 and OX40.

    • Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

      Benveniste et al. have uncovered γδ T cells that recognize peptide antigens in an MHC-restricted manner.

    • Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

      Ectopic expression of transcription factors PU.1, IRF8, and BATF3 reprograms fibroblasts to dendritic cells.

  • Review

    • Neutrophils: New insights and open questions

      Neutrophils patrol the bloodstream and tissues to kill microbes and guide subsequent innate and adaptive immune responses.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER "Induced" Dendritic Cells. In this issue, Rosa et al. report that ectopic expression of three transcription factors—PU.1, IRF8, and BATF3—is sufficient to reprogram mouse and human fibroblasts into "induced" dendritic cells. Featured on the cover is a colored scanning electron micrograph showing an "induced" dendritic cell with prominent cytoplasmic protrusions. [CREDIT: JONAS AHLSTEDT & SEBASTIAN WASSERSTROM/LUND UNIVERSITY BIOIMAGING CENTER]