Research ArticleT CELL MEMORY

TRM maintenance is regulated by tissue damage via P2RX7

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Science Immunology  14 Dec 2018:
Vol. 3, Issue 30, eaau1022
DOI: 10.1126/sciimmunol.aau1022

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Tissue damage triggers a TRM trim down

Noncirculating tissue-resident memory T cells (TRM) provide rapid host defense after reexposure to a previously encountered pathogen. Stark et al. found that TRM in the liver and small intestine expressed high levels of the P2RX7 purinergic receptor compared with circulating T cells. Release of extracellular nucleotides that are P2RX7 ligands (ATP and NAD+) in a mouse model of sterile liver injury selectively enhanced the death of liver TRM compared with circulating T cells, whereas concurrent TCR engagement promoted survival of TRM. These findings help define the signaling pathways that shape the clonal composition of the TRM compartment on an ongoing basis.