Research ArticleCYTOKINES

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

See allHide authors and affiliations

Science Immunology  21 Dec 2018:
Vol. 3, Issue 30, eaau6759
DOI: 10.1126/sciimmunol.aau6759

Article Information

vol. 3 no. 30

PubMed: 
Published By: 
History: 
  • Received July 23, 2018
  • Accepted November 20, 2018
  • .

Author Information

  1. Rubén Martínez-Barricarte1,*,
  2. Janet G. Markle1,*,,,
  3. Cindy S. Ma2,§,
  4. Elissa K. Deenick2,§,
  5. Noé Ramírez-Alejo1,§,
  6. Federico Mele3,§,
  7. Daniela Latorre3,§,
  8. Seyed Alireza Mahdaviani4,§,
  9. Caner Aytekin5,§,
  10. Davood Mansouri4,§,
  11. Vanessa L. Bryant6,7,8,§,
  12. Fabienne Jabot-Hanin9,
  13. Caroline Deswarte9,10,
  14. Alejandro Nieto-Patlán9,
  15. Laura Surace11,
  16. Gaspard Kerner9,10,
  17. Yuval Itan1,12,
  18. Sandra Jovic3,
  19. Danielle T. Avery2,
  20. Natalie Wong2,
  21. Geetha Rao2,
  22. Etienne Patin13,14,15,
  23. Satoshi Okada16,
  24. Benedetta Bigio1,
  25. Bertrand Boisson1,9,10,
  26. Franck Rapaport1,
  27. Yoann Seeleuthner9,10,
  28. Monika Schmidt17,
  29. Aydan Ikinciogullari18,
  30. Figen Dogu18,
  31. Gonul Tanir19,
  32. Payam Tabarsi4,
  33. Mohammed Reza Bloursaz4,
  34. Julia K. Joseph1,
  35. Avneet Heer1,
  36. Xiao-Fei Kong1,
  37. Mélanie Migaud9,10,
  38. Tomi Lazarov20,
  39. Frédéric Geissmann20,21,22,
  40. Bernhard Fleckenstein17,
  41. Cecilia Lindestam Arlehamn23,
  42. Alessandro Sette23,24,
  43. Anne Puel1,9,10,
  44. Jean-François Emile25,
  45. Esther van de Vosse26,
  46. Lluis Quintana-Murci13,14,15,
  47. James P. Di Santo11,
  48. Laurent Abel1,9,10,
  49. Stéphanie Boisson-Dupuis1,9,10,,
  50. Jacinta Bustamante1,9,10,27,,
  51. Stuart G. Tangye2,,
  52. Federica Sallusto3,28, and
  53. Jean-Laurent Casanova1,9,10,29,30,
  1. 1St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
  2. 2Immunology Division, Garvan Institute of Medical Research and St Vincent’s Clinical School, Faculty of Medicine, University of NSW, Sydney, New South Wales, Australia.
  3. 3Center of Medical Immunology, Institute for Research in Biomedicine, Faculty of Biomedical Sciences, University of italian Switzerland (USI), Bellinzona, Switzerland.
  4. 4Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  5. 5Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
  6. 6Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
  7. 7Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
  8. 8Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Parkville, Victoria, Australia.
  9. 9Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
  10. 10Paris Descartes University, Imagine Institute, Paris, France.
  11. 11Innate Immunity Unit, Pasteur Institute, INSERM U1223, Paris, France.
  12. 12Charles Bronfman Institute for Personalized Medicine, and the Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  13. 13Human Evolutionary Genetics Unit, Department of Genomes and Genetics, Pasteur Institute, Paris, France.
  14. 14Centre National de la Recherche Scientifique, UMR 2000, Paris, France.
  15. 15Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France.
  16. 16Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.
  17. 17Institute for Clinical and Molecular Virology, University Erlangen-Nuremberg,Erlangen, Germany.
  18. 18Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.
  19. 19Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
  20. 20Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  21. 21Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
  22. 22Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London, UK.
  23. 23Department of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
  24. 24Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  25. 25EA4340 and Pathology Department, Ambroise Paré Hospital AP-HP, Versailles Saint-Quentin-en-Yvelines University, Paris-Saclay University, Boulogne, France.
  26. 26Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
  27. 27Study Center of Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France.
  28. 28Institute of Microbiology, ETH Zurich, Switzerland.
  29. 29Howard Hughes Medical Institute, New York, NY, USA.
  30. 30Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children AP-HP, Paris, France.
  1. Corresponding author. Email: jmarkle1{at}jhu.edu (J.G.M.); jean-laurent.casanova{at}rockefeller.edu (J.-L.C.)
  • * These authors contributed equally to this work.

  • Present address: The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

  • § These authors contributed equally to this work.

  • These authors contributed equally to this work.

Altmetric

Article usage

Article usage: December 2018 to December 2019

AbstractFullPdf
Dec 201806447755
Jan 201915301865409
Feb 201935511063
Mar 20194378457
Apr 20192857754
May 20192236035
Jun 20191374727
Jul 20191303119
Aug 2019974328
Sep 20198112454
Oct 201913287118
Nov 20191139137
Dec 20195632