Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

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Science Immunology  14 Dec 2018:
Vol. 3, Issue 30, eaav4036
DOI: 10.1126/sciimmunol.aav4036

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γδ T cells come to the fore

Studies on T cells within the tumor microenvironment (TME) have largely focused on T cells that express αβ T cell receptors (TCRs). Using an in vitro culture system to expand melanoma antigen–specific T cells, Benveniste et al. have identified γδ T cells that recognize melanoma antigens in a class I MHC–restricted manner. To understand how these T cells recognize antigens in an MHC-restricted fashion, they crystallized one of these γδ TCRs complexed with cognate peptide, MHC, and β2 microglobulin. Given the success of T cell–centric therapies in cancer, the results presented here call for a closer examination of the role of γδ T cells in the TME of melanomas and other cancers.