Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

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Science Immunology  14 Dec 2018:
Vol. 3, Issue 30, eaav4036
DOI: 10.1126/sciimmunol.aav4036

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  • RE: Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells
    • Dianne Sika-Paotonu, Associate Dean (Pacific)/Senior Lecturer Pathology & Molecular Medicine, Wellington School of Medicine & Health Sciences, University of Otago, New Zealand

    To the Editor,

    I read with interest the research article prepared by Benveniste P. M., et al. (1) and entitled: “Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells.”

    T cells carrying αβ T cell receptors (TCRs) recognise antigen in the context of major histocompatibility complex (MHC). Although γδ T cells can recognise nonclassical MHC, the method of antigenic recognition by γδ T cells is unknown. It has also been suggested that antigen recognition by γδ T cells is similar to that of immunoglobulin.

    This work used human γδ T cells to explore the possibility of recognising melanoma associated antigens (MAAs) by engaging MHC-presented peptide antigens. An in-vitro system was used to generate antigen-specific human T cells which showed that γδ T cells could recognise MAAs, MART-1 and gp100 in an MHC-restricted manner.

    Crystal structure analysis showed that distinctive but also similar binding and docking properties exist for γδ T cells when compared with αβ T cells.

    A question which remains concerns how host γδ T cells are actually generated in the first instance and where exactly in the body these T cells will traffic to and from and reside within.

    Overall this work showed that γδ T cells that are MHC-restricted can be found in the periphery and have potential for use in the development of new TCR-based immunotherapeutic strategies.

    An encouraging set of results, acknowledging th...

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    Competing Interests: None declared.

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