January 2019
Vol 4, Issue 31

About The Cover

Cover image expansion

ONLINE COVER Nuclear F-Actin Network in Command. In this issue, Tsopoulidis et al. report that upon T cell activation, nuclear actin rapidly polymerizes into a dense filament network required for CD4+ T cell effector functions including cytokine production. Featured on the cover is a superresolution image prepared using stimulated emission depletion (STED) microscopy that demonstrates the nuclear F-actin network formed 30 seconds after T cell stimulation. [CREDIT: N. TSOPOULIDIS ET AL./SCIENCE IMMUNOLOGY]