Contents
January 2019
Vol 4, Issue 31
Vol 4, Issue 31
Research Articles
- Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation
In vivo reactivation of myelin-reactive T cells requires conventional DCs but not other brain-resident antigen-presenting cells.
- Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells
Impaired activity of enolase 1 limits glycolysis and effector function of tumor-infiltrating CD8+ T cells.
- Human “TH9” cells are a subpopulation of PPAR-γ+ TH2 cells
The transcription factor PPAR-γ plays a vital role in the generation of IL-9–producing TH cells.
- Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity
Intratumoral Treg cells are tumor/neoantigen reactive.
- T cell receptor–triggered nuclear actin network formation drives CD4+ T cell effector functions
This study defines calcium-dependent actin polymerization by nuclear Arp2/3 complex as essential for CD4+ T cell help.
Review
- Immune responses at the maternal-fetal interface
The placenta promotes tolerance of the semiallogeneic fetus while protecting against vertical transmission of infections.
Editors' Choice
- Inflammatory T cells maintain a healing disposition
Commensal-specific T cells dually possess type-2 and type-17 effector potential, allowing plasticity in orchestrating tissue immunity.
- Hurry up and wait, then activate and translate!
The immunometabolic pivot from reliance on fatty acid oxidation to glycolysis during T cell activation is reliant on the regulation of translation of key metabolic enzymes.
About The Cover
ONLINE COVER Nuclear F-Actin Network in Command. In this issue, Tsopoulidis et al. report that upon T cell activation, nuclear actin rapidly polymerizes into a dense filament network required for CD4+ T cell effector functions including cytokine production. Featured on the cover is a superresolution image prepared using stimulated emission depletion (STED) microscopy that demonstrates the nuclear F-actin network formed 30 seconds after T cell stimulation. [CREDIT: N. TSOPOULIDIS ET AL./SCIENCE IMMUNOLOGY]