Research ArticleT CELLS

T cell receptor–triggered nuclear actin network formation drives CD4+ T cell effector functions

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Science Immunology  04 Jan 2019:
Vol. 4, Issue 31, eaav1987
DOI: 10.1126/sciimmunol.aav1987

T cells need nuclear F-actin

T cell activation is regulated by numerous mechanisms upon T cell antigen receptor (TCR) engagement, including induction of specific cytokines by transcription factors like NF-κB and NFAT. Tsopoulidis et al. now show that TCR engagement causes rapid nuclear actin polymerization to create a dynamic actin filament network that is critical to CD4+ T cell effector functions. Nuclear actin filament polymerization involves the nuclear Arp2/3 complex that is induced by nuclear Ca2+ and regulated by N-Wasp and NIK. Specific inhibition of nuclear actin filament formation impairs T cell effector responses, including cytokine expression and CD4+ T cell help for antibody production. Together, these data reveal a role for nuclear actin filaments in driving CD4+ T cell effector functions.

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