Research ArticleTHYMIC SELECTION

The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

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Science Immunology  15 Feb 2019:
Vol. 4, Issue 32, eaal2201
DOI: 10.1126/sciimmunol.aal2201

Article Information

vol. 4 no. 32

PubMed: 
Published By: 
History: 
  • Received October 14, 2016
  • Accepted January 17, 2019
  • .

Author Information

  1. Steven C. Neier1,2,*,,
  2. Alejandro Ferrer1,,
  3. Katelynn M. Wilton1,2,3,,
  4. Stephen E. P. Smith1,,,
  5. April M. H. Kelcher1,2,4,
  6. Kevin D. Pavelko1,
  7. Jenna M. Canfield5,
  8. Tessa R. Davis1,
  9. Robert J. Stiles1,
  10. Zhenjun Chen6,
  11. James McCluskey6,
  12. Scott R. Burrows7,8,
  13. Jamie Rossjohn9,10,11,
  14. Deanne M. Hebrink12,
  15. Eva M. Carmona12,
  16. Andrew H. Limper12,
  17. Dietmar J. Kappes13,
  18. Peter J. Wettstein1,14,
  19. Aaron J. Johnson1,4,
  20. Larry R. Pease1,
  21. Mark A. Daniels15,16,
  22. Claudia Neuhauser17,
  23. Diana Gil15,16,18,§ and
  24. Adam G. Schrum15,16,18,§
  1. 1Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  2. 2Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN, USA.
  3. 3Medical Scientist Training Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
  4. 4Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  5. 5Molecular Pathogenesis and Therapeutics PhD Graduate Program, University of Missouri, Columbia, MO, USA.
  6. 6Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
  7. 7QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  8. 8School of Medicine, University of Queensland, Brisbane, Queensland 4006, Australia.
  9. 9Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  10. 10ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  11. 11Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
  12. 12Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
  13. 13Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
  14. 14Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
  15. 15Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.
  16. 16Department of Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.
  17. 17University of Minnesota Informatics Institute, Minneapolis, MN, USA.
  18. 18Department of Bioengineering, College of Engineering, University of Missouri, Columbia, MO, USA.
  1. §Corresponding author. Email: schruma{at}health.missouri.edu (A.G.S.); gilpagesd{at}health.missouri.edu (D.G.)
  • * Present address: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA, USA.

  • These authors contributed equally to this work.

  • Present address: Center for Integrative Brain Research, Seattle Children’s Research Institute and Department of Pediatrics, University of Washington, Seattle, WA, USA.

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