Research ArticleTYPE 1 DIABETES

Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children

See allHide authors and affiliations

Science Immunology  01 Feb 2019:
Vol. 4, Issue 32, eaau8125
DOI: 10.1126/sciimmunol.aau8125

Prediabetic microbiome

Studies in humans and mice have identified associations between intestinal microbiome composition and development of autoimmune diseases, including type 1 diabetes (T1D). How these microbes exert influence on immune responses in distant tissues is unknown. By studying pediatric cohorts, Paun et al. examined whether serum antibody responses to intestinal commensal bacteria were associated with T1D status. They report that antibody responses against specific commensals measured before T1D diagnosis distinguished individuals with islet autoantibodies from healthy controls in a human leukocyte antigen haplotype–dependent manner. Their results link immune responses to gut microbes with later T1D development and suggest that they may be predictive of T1D when analyzed with genetic risk factors.

View Full Text

Stay Connected to Science Immunology