March 2019
Vol 4, Issue 33

About The Cover

Cover image expansion

ONLINE COVER Clonality of the Dendritic Cell Network in Tissues. This issue's cover illustration is a Voronoi transformation of a fluorescence microscopy image showing conventional dendritic cell (cDC) clusters in the small intestine of a cDC-specific Confetti mouse. Colors depict distinct fluorescent proteins. Cabeza-Cabrerizo et al. analyze these images to show that cDCs are often organized in tissues as clusters of sister cells that must have divided locally before or after terminal differentiation. Infection can break up these clusters, in part by inducing rapid influx of cDCs precursors that intermingle into the existing mosaic. [CREDIT: MAR CABEZA-CABRERIZO AND DANIEL HEIM]