Research ArticleLYMPHOCYTE HOMING

Clever-1 contributes to lymphocyte entry into the spleen via the red pulp

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Science Immunology  29 Mar 2019:
Vol. 4, Issue 33, eaat0297
DOI: 10.1126/sciimmunol.aat0297

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Splenic portal for lymphocyte entry

Lymphocytes traveling through the body alternate between periods of residence in lymphoid organs and periods of circulation in blood and lymphatic vessels. Tadayon et al. used adoptive transfer of labeled lymphocytes to investigate where circulating lymphocytes first exit the vasculature of the mouse spleen to gain access to the lymphocyte-rich splenic white pulp. A majority of lymphocytes were found in the red pulp zone of the spleen 10 min after transfer. The Clever-1 adhesion and scavenger receptor on endothelial cells was identified as an important facilitator of initial entry of B cells and CD8+ T cells into the red pulp. These findings point to the existence of distinct molecular mechanisms governing how lymphocytes traffic into the spleen compared with the lymph nodes.

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