CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

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Science Immunology  15 Mar 2019:
Vol. 4, Issue 33, eaav1263
DOI: 10.1126/sciimmunol.aav1263

Getting immune cells home

Immune cells are recruited to tissues from the lymphatic system via efferent lymphatics in response to insults ranging from skin allergies to flu infection. Immune cells recirculate back to draining lymph nodes via afferent lymphatics. Using a combination of in vitro systems and in vivo studies, Xiong et al. have examined the role of sphingosine 1-phosphate (S1P) and its receptors (S1PRs) in the egress of T cells from tissues. They found expression of S1PR1 and S1PR4 on T cells and engagement of S1PR2 on lymphatic endothelial cells to be important for this process. Whereas the role of S1PRs in recruitment of lymphocytes to tissues is well established, the current study extends their importance to recirculation of immune cells back to the lymphatic system.

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