Generation and persistence of human tissue-resident memory T cells in lung transplantation

See allHide authors and affiliations

Science Immunology  08 Mar 2019:
Vol. 4, Issue 33, eaav5581
DOI: 10.1126/sciimmunol.aav5581

Transplanted memories

Parabiosis experiments in mice have shaped our understanding of the tissue retention properties of tissue-resident memory T cells (TRM). By studying donor and recipient T cells in transplanted lungs, Snyder et al. have provided a rare glimpse into the generation and maintenance of human TRM. Whereas donor T cells were barely detectable in blood within 10 weeks after transplantation, donor TRM were abundant and persisted in transplanted lungs for more than a year. Recipient T cells infiltrating the lung gradually acquired TRM profiles over time as determined by analyses of T cells from bronchoalveolar lavages. In this 20-patient cohort, persistence of donor lung TRM correlated with improved clinical outcome, although further studies are needed to understand their role in graft retention.

View Full Text

Stay Connected to Science Immunology