Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

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Science Immunology  01 Mar 2019:
Vol. 4, Issue 33, eaaw1941
DOI: 10.1126/sciimmunol.aaw1941

Dendritic cell dynamics

Conventional dendritic cells (cDCs) are critical to innate immunity and orchestrating adaptive T cell responses. cDCs originate from a common precursor and can be delineated into different subtypes. Cabeza-Cabrerizo et al. use multicolor fate mapping in mice to show that precursor cDCs enter tissue, differentiate into a single subtype, and proliferate as clones of sister cDCs under steady-state conditions. Viral infection causes a rapid influx of cDCs into infected tissue, and these cells differentiate into tissue-resident cDCs and dilute preexisting cDC clones. These results provide insight into cDC dynamics in tissues and how infection can cause rapid changes in cDC population frequencies.

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