Research ArticleINNATE IMMUNITY
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors
- View ORCID ProfileMar Cabeza-Cabrerizo1,*,†,
- Janneke van Blijswijk1,*,†,
- Stephan Wienert2,‡,
- View ORCID ProfileDaniel Heim2,
- View ORCID ProfileRobert P. Jenkins3,
- View ORCID ProfileProbir Chakravarty4,
- Neil Rogers1,
- View ORCID ProfileBruno Frederico1,
- View ORCID ProfileSophie Acton1,§,
- Evelyne Beerling5,||,
- Jacco van Rheenen5,||,
- View ORCID ProfileHans Clevers5,
- View ORCID ProfileBarbara U. Schraml1,¶,
- Marc Bajénoff6,
- View ORCID ProfileMichael Gerner7,#,
- Ronald N. Germain7,
- View ORCID ProfileErik Sahai3,
- Frederick Klauschen2,† and
- View ORCID ProfileCaetano Reis e Sousa1,†
- 1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
- 2Institute of Pathology, Charité University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
- 3Tumour Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
- 4Bioinformatics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
- 5Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
- 6Aix-Marseille University Centre, National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Immunologie de Marseille-Luminy (CIML), Marseille, France.
- 7Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵†Corresponding author. Email: caetano{at}crick.ac.uk (C.R.e.S); mar.cabeza-cabrerizo{at}crick.ac.uk (M.C.-C.); jannekevanblijswijk{at}gmail.com (J.v.B.); frederick.klauschen{at}charite.de (F.K.)
↵* These authors contributed equally to this work.
↵‡ Present address: dlw Laborsoftware UG, Kastanienallee 36, 15907 Lübben, Germany.
↵§ Present address: MRC Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, UK.
↵|| Present address: Netherlands Cancer Institute, Division of Molecular Pathology, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.
↵¶ Present address: Walter-Brendel-Centre for Experimental Medicine, University Hospital, LMU Munich, Grosshaderner Strasse 9, 82152 Planegg-Martinsried and Biomedical Center, LMU Munich, Grosshaderner Strasse 9, 82152 Planegg-Martinsried, Germany.
↵# Present address: Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
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Science Immunology 01 Mar 2019:
Vol. 4, Issue 33, eaaw1941
DOI: 10.1126/sciimmunol.aaw1941
Vol. 4, Issue 33, eaaw1941
DOI: 10.1126/sciimmunol.aaw1941
Mar Cabeza-Cabrerizo
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Janneke van Blijswijk
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stephan Wienert
2Institute of Pathology, Charité University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
Daniel Heim
2Institute of Pathology, Charité University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
Robert P. Jenkins
3Tumour Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Probir Chakravarty
4Bioinformatics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Neil Rogers
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Bruno Frederico
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Sophie Acton
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Evelyne Beerling
5Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
Jacco van Rheenen
5Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
Hans Clevers
5Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
Barbara U. Schraml
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Marc Bajénoff
6Aix-Marseille University Centre, National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Immunologie de Marseille-Luminy (CIML), Marseille, France.
Michael Gerner
7Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ronald N. Germain
7Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Erik Sahai
3Tumour Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Frederick Klauschen
2Institute of Pathology, Charité University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
Caetano Reis e Sousa
1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
