Research ArticleIMMUNOGENOMICS

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

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Science Immunology  26 Apr 2019:
Vol. 4, Issue 34, eaau7523
DOI: 10.1126/sciimmunol.aau7523

Article Information

vol. 4 no. 34

PubMed: 
Published By: 
History: 
  • Received July 11, 2018
  • Accepted March 19, 2019
  • .

Author Information

  1. Chan-Wang J. Lio1,*,,
  2. Vipul Shukla1,,
  3. Daniela Samaniego-Castruita1,,
  4. Edahi González-Avalos1,,
  5. Abhijit Chakraborty2,
  6. Xiaojing Yue1,
  7. David G. Schatz3,
  8. Ferhat Ay2 and
  9. Anjana Rao1,4,5,6,*
  1. 1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
  2. 2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.
  3. 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  4. 4Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.
  5. 5Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.
  6. 6Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.
  1. *Corresponding author. Email: arao{at}lji.org (A.R.); lio{at}lji.org (C.-W.J.L.)
  • These authors contributed equally to this work.

  • These authors contributed equally to this work.

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