TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

Chan-Wang J. Lio; Vipul Shukla; Daniela Samaniego-Castruita; Edahi González-Avalos; Abhijit Chakraborty; Xiaojing Yue; David G. Schatz; Ferhat Ay; Anjana Rao

doi:10.1126/sciimmunol.aau7523

Research ArticleIMMUNOGENOMICS

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

View ORCID ProfileChan-Wang J. Lio ¹,*,†,
View ORCID ProfileVipul Shukla ¹,†,
View ORCID ProfileDaniela Samaniego-Castruita ¹,‡,
Edahi González-Avalos ¹,‡,
Abhijit Chakraborty²,
Xiaojing Yue¹,
View ORCID ProfileDavid G. Schatz ³,
View ORCID ProfileFerhat Ay ² and
Anjana Rao ¹,⁴,⁵,⁶,*

¹Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
²Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.
³Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
⁴Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.
⁵Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.
⁶Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

↵*Corresponding author. Email: arao{at}lji.org (A.R.); lio{at}lji.org (C.-W.J.L.)

↵† These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science Immunology 26 Apr 2019:
Vol. 4, Issue 34, eaau7523
DOI: 10.1126/sciimmunol.aau7523

Chan-Wang J. Lio

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

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For correspondence: arao@lji.org lio@lji.org

Vipul Shukla

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

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Daniela Samaniego-Castruita

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

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Edahi González-Avalos

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

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Abhijit Chakraborty

2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.

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Xiaojing Yue

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

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David G. Schatz

3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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Ferhat Ay

2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.

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Anjana Rao

1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

4Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.

5Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.

6Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

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For correspondence: arao@lji.org lio@lji.org

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TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

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