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Research ArticleIMMUNOGENOMICS
TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer
- View ORCID ProfileChan-Wang J. Lio1,*,†,
- View ORCID ProfileVipul Shukla1,†,
- View ORCID ProfileDaniela Samaniego-Castruita1,‡,
- Edahi González-Avalos1,‡,
- Abhijit Chakraborty2,
- Xiaojing Yue1,
- View ORCID ProfileDavid G. Schatz3,
- View ORCID ProfileFerhat Ay2 and
- Anjana Rao1,4,5,6,*
- 1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
- 2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.
- 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
- 4Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.
- 5Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.
- 6Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.
- ↵*Corresponding author. Email: arao{at}lji.org (A.R.); lio{at}lji.org (C.-W.J.L.)
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Science Immunology 26 Apr 2019:
Vol. 4, Issue 34, eaau7523
DOI: 10.1126/sciimmunol.aau7523
Vol. 4, Issue 34, eaau7523
DOI: 10.1126/sciimmunol.aau7523
Chan-Wang J. Lio
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
Vipul Shukla
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
Daniela Samaniego-Castruita
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
Edahi González-Avalos
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
Abhijit Chakraborty
2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.
Xiaojing Yue
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
David G. Schatz
3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Ferhat Ay
2Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.
Anjana Rao
1Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.
4Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.
5Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.
6Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.
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