Research ArticleAUTOIMMUNITY

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes

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Science Immunology  05 Apr 2019:
Vol. 4, Issue 34, eaav7517
DOI: 10.1126/sciimmunol.aav7517

Article Information

vol. 4 no. 34

PubMed: 
Published By: 
History: 
  • Received October 16, 2018
  • Revision received January 4, 2019
  • Accepted February 11, 2019
  • .

Author Information

  1. Yang Wang1,2,*,
  2. Tomasz Sosinowski3,,
  3. Andrey Novikov1,*,
  4. Frances Crawford1,
  5. Janice White1,
  6. Niyun Jin1,3,
  7. Zikou Liu1,,
  8. Jinhao Zou1,§,
  9. David Neau4,
  10. Howard W. Davidson2,3,
  11. Maki Nakayama2,3,
  12. William W. Kwok5,
  13. Laurent Gapin2,
  14. Philippa Marrack1,2,6,
  15. John W. Kappler1,2,3,7,|| and
  16. Shaodong Dai1,2,7,*,||
  1. 1Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
  2. 2Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  3. 3Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  4. 4Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.
  5. 5Benaroya Research Institute, Seattle, WA 98101, USA.
  6. 6Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  7. 7Structural Biology and Biochemistry program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  1. ||Corresponding author. Email: kapplerj{at}njhealth.org (J.W.K.); shaodong.dai{at}ucdenver.edu (S.D.)
  • * Present address: Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

  • Present address: Biocheck Inc., 425 Eccles Avenue, South San Francisco, CA 94080, USA.

  • Present address: Division of Cell Signaling and Cell Death, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia.

  • § Present address: UTHealth Graduate School of Biomedical Science, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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