May 2019
Vol 4, Issue 35

About The Cover

Cover image expansion

ONLINE COVER Adiposphere Mound. This month's cover shows a stack of two 3D organoids grown from distinct subtypes of mesenchymal stromal cells found in visceral adipose tissue. These spherical organoids were generated using adipogenic media and stained with dyes that bound to nuclear DNA (blue) or fat droplets (green). Spallanzani et al. used single-cell RNA sequencing to identify which subtypes of stromal cells within white fat make interleukin-33 (IL-33), a cytokine that supports maintenance of regulatory T cells and group 2 innate lymphoid cells within visceral adipose tissue. [CREDIT: RAUL GERMÁN SPALLANZANI]