Research ArticleINNATE IMMUNITY

Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations

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Science Immunology  31 May 2019:
Vol. 4, Issue 35, eaau8082
DOI: 10.1126/sciimmunol.aau8082

Innate drifters

Innate lymphoid cells (ILCs) are regarded as tissue-resident sentries that stay put in peripheral tissues or lymphoid organs rather than extensively recirculating like most B and T cells. Dutton et al. used direct illumination to mark all cells in a single peripheral lymph node of transgenic mice expressing a photoconvertible fluorescent reporter protein. Migration versus continuing residence of the marked cells was monitored by flow cytometry. This experimental approach showed that ILC1s in a lymph node have more propensity to migrate away from that lymph node than ILC2s and ILC3s but still considerably less than T cells. The findings from this study reveal that some ILC subsets are not exclusively sessile and routinely traffic between different anatomic sites while carrying out their immunosurveillance mission.

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