Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations

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Science Immunology  31 May 2019:
Vol. 4, Issue 35, eaau8082
DOI: 10.1126/sciimmunol.aau8082

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  • RE: Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations
    • Dianne Sika-Paotonu CQS MRSNZ, Associate Dean (Pacific)/Senior Lecturer Pathology & Molecular Medicine, Wellington School of Medicine & Health Sciences, University of Otago, New Zealand

    To the Editor,

    I read with very keen interest the article by Dutton, E. E. et al. (1) and titled “Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations”.

    Innate lymphoid cell (ILC) populations were previously considered confided to lymphoid organ and peripheral tissues. This work however provided clear evidence to show that ILC1 type cell populations displayed migratory function when compared with the ILC2 and ILC3 types.

    Using direct illumination to label brachial LN cells expressing photoconvertible fluorescent protein in transgenic mice, the authors were able to track cellular migration patterns of cells entering various tissues.

    This work indeed showed that peripheral lymph nodes contained migratory cells and that these were predominantly of the ILC1 subset.

    These ILC1 cells were also shown to display conventional natural killer (cNK) characteristics and entered the LNs from the circulation via CD62L and CCR7 dependent mechanisms, recirculating through peripheral LNs and egressing via an S1P receptor dependent mechanism.

    Overall this work identified previously unidentified patterns of migratory behaviour for peripheral LN ILC populations – in particular for the ILC1 subtype and highlighted continuous trafficking between the circulation and peripheral LNs.

    An interesting set of studies with important relevance associated with the regulation of adaptive immune responses in the lympho...

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    Competing Interests: None declared.

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