Research ArticleEMERGING INFECTIONS
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
- Nurgun Kose1,
- View ORCID ProfileJulie M. Fox2,
- View ORCID ProfileGopal Sapparapu1,3,
- Robin Bombardi1,
- View ORCID ProfileRashika N. Tennekoon4,
- View ORCID ProfileA. Dharshan de Silva4,5,
- View ORCID ProfileSayda M. Elbashir6,
- View ORCID ProfileMatthew A. Theisen6,
- View ORCID ProfileElisabeth Humphris-Narayanan6,
- View ORCID ProfileGiuseppe Ciaramella6,
- View ORCID ProfileSunny Himansu6,
- View ORCID ProfileMichael S. Diamond2,7 and
- James E. Crowe Jr.1,3,8,*
- 1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
- 2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
- 3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 4Genetech Research Institute, Colombo, Sri Lanka.
- 5Department of Paraclinical Sciences, Faculty of Medicine, Kotelawala Defence University, Sri Lanka.
- 6Moderna Therapeutics, Cambridge, MA, USA.
- 7Department of Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
- 8Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
- ↵*Corresponding author. Email: james.crowe{at}vanderbilt.edu
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Science Immunology 17 May 2019:
Vol. 4, Issue 35, eaaw6647
DOI: 10.1126/sciimmunol.aaw6647
Vol. 4, Issue 35, eaaw6647
DOI: 10.1126/sciimmunol.aaw6647
Nurgun Kose
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Julie M. Fox
2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Gopal Sapparapu
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Robin Bombardi
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Rashika N. Tennekoon
4Genetech Research Institute, Colombo, Sri Lanka.
A. Dharshan de Silva
4Genetech Research Institute, Colombo, Sri Lanka.
5Department of Paraclinical Sciences, Faculty of Medicine, Kotelawala Defence University, Sri Lanka.
Sayda M. Elbashir
6Moderna Therapeutics, Cambridge, MA, USA.
Matthew A. Theisen
6Moderna Therapeutics, Cambridge, MA, USA.
Elisabeth Humphris-Narayanan
6Moderna Therapeutics, Cambridge, MA, USA.
Giuseppe Ciaramella
6Moderna Therapeutics, Cambridge, MA, USA.
Sunny Himansu
6Moderna Therapeutics, Cambridge, MA, USA.
Michael S. Diamond
2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
7Department of Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
James E. Crowe Jr.
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
8Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
