Research ArticleEMERGING INFECTIONS
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
- Nurgun Kose1,
- Julie M. Fox2,
- Gopal Sapparapu1,3,
- Robin Bombardi1,
- Rashika N. Tennekoon4,
- A. Dharshan de Silva4,5,
- Sayda M. Elbashir6,
- Matthew A. Theisen6,
- Elisabeth Humphris-Narayanan6,
- Giuseppe Ciaramella6,
- Sunny Himansu6,
- Michael S. Diamond2,7 and
- James E. Crowe Jr.1,3,8,*
- 1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
- 2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
- 3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 4Genetech Research Institute, Colombo, Sri Lanka.
- 5Department of Paraclinical Sciences, Faculty of Medicine, Kotelawala Defence University, Sri Lanka.
- 6Moderna Therapeutics, Cambridge, MA, USA.
- 7Department of Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
- 8Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
- ↵*Corresponding author. Email: james.crowe{at}vanderbilt.edu
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Science Immunology 17 May 2019:
Vol. 4, Issue 35, eaaw6647
DOI: 10.1126/sciimmunol.aaw6647
