A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Research ArticleEMERGING INFECTIONS

¹Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
²Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
³Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴Genetech Research Institute, Colombo, Sri Lanka.
⁵Department of Paraclinical Sciences, Faculty of Medicine, Kotelawala Defence University, Sri Lanka.
⁶Moderna Therapeutics, Cambridge, MA, USA.
⁷Department of Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
⁸Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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Science Immunology 17 May 2019:
Vol. 4, Issue 35, eaaw6647
DOI: 10.1126/sciimmunol.aaw6647

Nurgun Kose

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Julie M. Fox

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Gopal Sapparapu

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Robin Bombardi

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Rashika N. Tennekoon

Genetech Research Institute, Colombo, Sri Lanka.

A. Dharshan de Silva

Genetech Research Institute, Colombo, Sri Lanka.

Department of Paraclinical Sciences, Faculty of Medicine, Kotelawala Defence University, Sri Lanka.

Sayda M. Elbashir