Research ArticleSTROMAL CELLS

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

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Science Immunology  03 May 2019:
Vol. 4, Issue 35, eaax0416
DOI: 10.1126/sciimmunol.aax0416

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Stromal sources of IL-33 in fat depots

White adipose tissue (WAT) is home to Tregs and group 2 innate lymphoid cells (ILC2s) that help keep inflammation under check. Two studies in this week’s issue probe WAT in search of cells producing the alarmin cytokine interleukin-33 (IL-33) that regulates Tregs and ILC2s. Spallanzani et al. used single-cell RNA sequencing to characterize visceral WAT stromal cells and defined five distinct subtypes, with subtypes 1 to 3 producing IL-33 and subtypes 4 and 5 resembling adipocyte precursors. Mahlakõiv et al. identified adipose stem and progenitor cells as a source of IL-33 in all WAT depots and mesothelial cells as an additional source of IL-33 in visceral WAT. These studies improve our understanding of WAT stromal cell diversity and how the stromal cell landscape responds to physiological or pathological variations. See related Research Article by Spallanzani et al.