Research ArticleANTIBODIES

B cells engineered to express pathogen-specific antibodies protect against infection

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Science Immunology  17 May 2019:
Vol. 4, Issue 35, eaax0644
DOI: 10.1126/sciimmunol.aax0644

B cells enter the cell therapy game

Antibodies are currently being used to treat a number of ailments from infectious diseases to cancers and autoimmunity. Like other drugs, patients often require multiple doses of antibodies. Because production and storage of antibodies are expensive, there has been considerable interest in finding alternative strategies to deliver antibodies. Here, Moffett et al. have engineered both human and murine B cells to express antibodies targeting a number of viruses, including respiratory syncytial virus (RSV), and report that a single injection of B cells expressing RSV-specific antibodies into mice lacking T and B to be protective. Their technology opens up the possibility of using engineered B cells as therapeutics.

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