Contents
June 2019
Vol 4, Issue 36
Vol 4, Issue 36
Focus
- Interleukin-17 receptor D: An orphan receptor finds a home in the skin
Interleukin-17 receptor D (IL-17RD) heterodimerizes with IL-17RA to form a receptor selective for the cytokine IL-17A. (See the related Research Article by Su et al.)
- Next stop: Perivasculature! ILC2s hitch a ride on the CCL8 express
CCL8-CCR8 axis and collagen-I regulate ILC2 cells during lung inflammation. (See the related Research Article by Puttur et al.).
Research Articles
- ATP release drives heightened immune responses associated with hypertension
Hypertension promotes ATP release from erythrocytes, leading to a P2X7-dependent increase in T cell–mediated immune responses.
- Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity
Activation of the necroptotic kinases RIPK1 and RIPK3 within the tumor microenvironment enhances immune-mediated tumor control.
- PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function
PD-L1+Ly6Clo monocytes derive from Ly6Chi monocytes in bone marrow and control T cell survival in tertiary lymphoid organs.
- IL-23–producing IL-10Rα–deficient gut macrophages elicit an IL-22–driven proinflammatory epithelial cell response
Proinflammatory IL-10R–deficient colonic macrophages trigger defined T cell and epithelial responses causing colitis.
- PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae
Exhausted-like CD8+ resident memory T cells in the lung limit immune activation–driven fibrosis.
- Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans
Collagen-I and CCL8-CCR8 axis control the motility of ILC2s in the inflamed lung.
- Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation
Interleukin-17 receptor D serves as a functional receptor for Interleukin-17A in psoriasis-like skin inflammation.
Editors' Choice
- Duel(ling) precursors in thymic Treg development
Functional thymus derived regulatory T cells can be generated by two distinct pathways.
About The Cover
ONLINE COVER Amoeboid Prowling by Lung ILC2s. Featured on the cover is a confocal image of a precision-cut mouse lung slice showing green group 2 innate lymphoid cells (ILC2s) in close proximity to peribronchial collagen fibers (in blue and magenta). Puttur et al. used intravital microscopy techniques to track the migration of ILC2s during IL-33–induced lung inflammation. These studies identify type I collagen and chemokines as key influences on the shape and locomotor activity of ILC2s during lung inflammation. [CREDIT: FRANZ PUTTUR ET AL./SCIENCE IMMUNOLOGY]
