Research ArticleINFLAMMATION

ATP release drives heightened immune responses associated with hypertension

See allHide authors and affiliations

Science Immunology  28 Jun 2019:
Vol. 4, Issue 36, eaau6426
DOI: 10.1126/sciimmunol.aau6426

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Hypertension-induced alarm signal fires up T cells

Human hypertension is a highly prevalent disease known to be associated with chronic low-grade inflammation. Zhao et al. used mouse models to look for hypertension-induced proinflammatory molecules that contribute to promoting T cell activation and propagating inflammation. Consistent elevations in plasma levels of the alarmin molecule ATP were identified in hypertensive mice. Increased ATP concentrations promoted T cell responses by enhancing expression of the CD86 costimulatory molecule on antigen-presenting cells, an effect mediated through the P2X7 purinergic receptor. Elevations of plasma ATP were also detected in a cohort of hypertensive human patients compared with normotensive controls. The results of this study identify ATP release and the ATP-P2X7 signaling axis as potential targets to help rein in the proinflammatory sequelae associated with chronic hypertension.

View Full Text