Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

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Science Immunology  07 Jun 2019:
Vol. 4, Issue 36, eaav7638
DOI: 10.1126/sciimmunol.aav7638

Filming the airways

Group 2 innate lymphoid cells (ILC2s) are key drivers of immune responses in the lung. Using an interleukin-13 (IL-13) reporter mouse strain in conjunction with sophisticated microscopy, Puttur et al. have visualized migration of ILC2s in allergic airway inflammation. They report that ILC2s exhibit dynamic ameboid-like movement in response to IL-33 and that IL-33–induced up-regulation of chemokine receptor 8 on ILC2s promotes homing of ILC2s to deposits of chemokine ligand 8 within the airways. They also found a role for collagen-I, a component of the extracellular matrix (ECM) in directly regulating migration of ILC2s. The study underscores the importance of how structural cues from the ECM work in conjunction with immune mediators to influence immune cell functions in tissues.