August 2019
Vol 4, Issue 38

About The Cover

Cover image expansion

ONLINE COVER Natural Killer Cell Dysfunction Compromises Placental Development. This month's cover is an artist's depiction of a 7-month-old human fetus in the amniotic sac, with the umbilical cord connecting the fetus to the placenta. Sliz et al. discovered that loss-of-function mutations in the mouse Gab3 adaptor protein cause impaired function of natural killer (NK) cells. One manifestation of this NK cell immunodeficiency is increased incidence of late-stage pregnancy complications due to placental abnormalities in Gab3-deficient mothers. [CREDIT: ISTOCK.COM/HENRIK5000]