Contents
August 2019
Vol 4, Issue 38
Vol 4, Issue 38
Focus
- Placentation and antitumor immunity regulated by a scaffolding protein in NK cells
Natural killer cells use the Gab3 adaptor protein to limit trophoblast invasion during pregnancy and to reject tumor cells. See the related Research Article by Sliz et al.
Research Articles
- Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
Onset of type 1 diabetes in NOD mice is triggered by the recognition of I-Ag7 insulin peptide complexes by islet CD4+ T cells.
- A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury
Following immune damage in the epidermis, monocytes from the circulation give rise to epidermal Langerhans cells.
- Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity
Proper dosing and timing of EGFR TKI can trigger antitumor T cell responses and potentiate anti–PD-L1 immunotherapy.
- Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy
NK cells require Gab3 for peripheral expansion, tumor eradication, and resistance to trophoblast invasion during pregnancy. See the related Focus by Colucci.
Technical Comment
- Comment on “A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands”
There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides.
Technical Response
- Response to Comment on “A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands”
This is our response to the Technical Comment by Rolfs et al. where we point out errors in their reanalysis of our data.
Editors' Choice
- Leukemic stem cells hiding in plain sight
Activation of NK-mediated immune surveillance clears leukemic stem cell populations.
- TB or not TB: Type 3 ILCs may decide
Mouse models are used to show that type 3 innate lymphoid cells provide early protection against Mtb infection.
About The Cover
ONLINE COVER Natural Killer Cell Dysfunction Compromises Placental Development. This month's cover is an artist's depiction of a 7-month-old human fetus in the amniotic sac, with the umbilical cord connecting the fetus to the placenta. Sliz et al. discovered that loss-of-function mutations in the mouse Gab3 adaptor protein cause impaired function of natural killer (NK) cells. One manifestation of this NK cell immunodeficiency is increased incidence of late-stage pregnancy complications due to placental abnormalities in Gab3-deficient mothers. [CREDIT: ISTOCK.COM/HENRIK5000]
