Research ArticleSKIN INFLAMMATION

A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury

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Science Immunology  23 Aug 2019:
Vol. 4, Issue 38, eaax8704
DOI: 10.1126/sciimmunol.aax8704

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Resurrecting sentinels in the skin

Langerhans cells are resident innate immune cells in the skin that play essential roles in promoting local immune responses and in maintaining skin homeostasis. Langerhans cells arise from fetal progenitors that seed the skin early in development. Here, Ferrer et al. have used a hematopoietic stem cell transplant model to examine the consequences of immune damage and loss of Langerhans cells in adult mouse skin. They report that monocytes from the blood infiltrate the skin and eventually replenish the Langerhans cell network, albeit the process by which monocytes give rise to Langerhans cells is not particularly efficient. Their findings are in agreement with studies reporting the ability of monocytes to replenish tissue-resident macrophages at other sites.

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