September 2019
Vol 4, Issue 39

About The Cover

Cover image expansion

ONLINE COVER Transcriptional Mirroring by Skin Tregs. This month's cover shows reflections in a bifold hand mirror. A transcriptomic analysis of skin-resident Tregs in mice by Kalekar et al. revealed that cutaneous Tregs express the GATA3 transcription factor that is required to prevent excess dermal fibrosis promoted by TH2 cells. The strategy of transcriptional "mirroring" used by tissue resident Tregs in multiple tissues including skin is discussed by Bal and Stadhouders in a related Focus [CREDIT: BAMBU PRODUCTIONS/GETTY IMAGES]