Contents
September 2019
Vol 4, Issue 39
Vol 4, Issue 39
Focus
- Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer
IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research Article by Papillion et al.).
- Tregs in fibrosis: To know your enemy, you must become your enemy
T helper 2–skewed regulatory T cells in the skin use GATA3 to suppress local profibrotic type 2 cytokine production. See the related Research Article by Kalekar et al.
Research Articles
- Myeloid cell–synthesized coagulation factor X dampens antitumor immunity
Rivaroxaban, an inhibitor of coagulation factor Xa, promotes antitumor immunity in mice.
- Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
Immunization with nucleoside-modified mRNA encoding herpes glycoproteins C, D, and E protects against genital herpes.
- RIG-I activation is critical for responsiveness to checkpoint blockade
Aberrant tumor-intrinsic RIG-I signaling is a crucial mechanism underlying cancer resistance to anti–CTLA-4 immunotherapy.
- Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells
IL-6–mediated inhibition of CD122 allows TFH cells to receive TCR signaling without initiating an inhibitory TCR/IL-2 loop (see the related Focus by Zhou and Yu)..
- Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses
Skin Tregs depend on GATA3 to attenuate immune cell–stimulated cutaneous fibrosis. See the related Focus by Bal and Stadhouders.
Review
- Gasdermin D activity in inflammation and host defense
This Review summarizes our current understanding of the functions of gasdermin D.
Editors' Choice
- Changing of the guard
Anti-PD-1 therapy induces clonal expansion of tumor-specific T cells with antigen specificities distinct from the tumor-specific T cells present before therapy.
- Sugar Mommy
During pregnancy, mothers generate di-galactosylated IgGs that cross the placenta more readily and provide the fetus and the newborn infant with antibodies optimized for NK cell–mediated antibody-dependent cellular cytotoxicity.
About The Cover
ONLINE COVER Transcriptional Mirroring by Skin Tregs. This month's cover shows reflections in a bifold hand mirror. A transcriptomic analysis of skin-resident Tregs in mice by Kalekar et al. revealed that cutaneous Tregs express the GATA3 transcription factor that is required to prevent excess dermal fibrosis promoted by TH2 cells. The strategy of transcriptional "mirroring" used by tissue resident Tregs in multiple tissues including skin is discussed by Bal and Stadhouders in a related Focus [CREDIT: BAMBU PRODUCTIONS/GETTY IMAGES]
