Research ArticleTUMOR IMMUNOLOGY

RIG-I activation is critical for responsiveness to checkpoint blockade

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Science Immunology  13 Sep 2019:
Vol. 4, Issue 39, eaau8943
DOI: 10.1126/sciimmunol.aau8943

Article Information

vol. 4 no. 39

PubMed: 
Published By: 
History: 
  • Received July 25, 2018
  • Revision received May 20, 2019
  • Accepted August 7, 2019
  • .

Author Information

  1. Simon Heidegger1,2,*,,
  2. Alexander Wintges1,,
  3. Florian Stritzke1,2,
  4. Sarah Bek1,
  5. Katja Steiger3,4,
  6. Paul-Albert Koenig4,5,6,
  7. Sascha Göttert1,2,
  8. Thomas Engleitner2,7,
  9. Rupert Öllinger2,7,
  10. Tatiana Nedelko1,2,
  11. Julius C. Fischer1,8,
  12. Vladimir Makarov9,
  13. Christof Winter4,5,
  14. Roland Rad2,4,7,10,
  15. Marcel R.M. van den Brink11,
  16. Jürgen Ruland2,4,5,
  17. Florian Bassermann1,2,4,
  18. Timothy A. Chan9,12,
  19. Tobias Haas1, and
  20. Hendrik Poeck1,2,*,
  1. 1Department of Medicine III, School of Medicine, Technical University of Munich, Munich, Germany.
  2. 2Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.
  3. 3Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
  4. 4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  5. 5Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.
  6. 6Core Facility Nanobodies, University of Bonn, Bonn, Germany.
  7. 7Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.
  8. 8Department of Radiation Oncology, School of Medicine, Technical University of Munich, Munich, Germany.
  9. 9Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, USA.
  10. 10Department of Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.
  11. 11Departments of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
  12. 12Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
  1. *Corresponding author. Email: simon.heidegger{at}tum.de (S.H.); hendrik.poeck{at}tum.de (H.P.)
  • These authors contributed equally to this work.

  • These authors share senior authorship.

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