Research ArticleLYMPHOCYTES

Lin28b controls a neonatal to adult switch in B cell positive selection

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Science Immunology  27 Sep 2019:
Vol. 4, Issue 39, eaax4453
DOI: 10.1126/sciimmunol.aax4453

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Sending B cells back in time

B-1 cells are a subset of self-reactive B cells that arise in early life. Precisely how and why the immune system permits the development of self-reactive B cells in neonates remains a mystery. Here, by studying B cell development in neonatal mice, Vanhee et al. have uncovered the importance of RNA binding protein Lin28b in facilitating positive selection of self-reactive B-1 cells in neonates. Further, they found that ectopic expression of Lin28b was sufficient to promote selection of self-reactive B-1 cells in adult mice. The authors propose that Lin28b functions as a cell-intrinsic switch that jumpstarts the generation of B cells in early life.

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