Research ArticleIMMUNE REGULATION

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19

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Science Immunology  25 Oct 2019:
Vol. 4, Issue 40, eaaw2707
DOI: 10.1126/sciimmunol.aaw2707

Article Information

vol. 4 no. 40

PubMed: 
Published By: 
History: 
  • Received December 4, 2018
  • Accepted September 26, 2019
  • .

Author Information

  1. Masahiko Akamatsu1,2,*,
  2. Norihisa Mikami3,4,*,
  3. Naganari Ohkura3,5,
  4. Ryoji Kawakami3,
  5. Yohko Kitagawa3,
  6. Atsushi Sugimoto3,
  7. Keiji Hirota4,
  8. Naoto Nakamura2,
  9. Satoru Ujihara2,
  10. Toshio Kurosaki2,
  11. Hisao Hamaguchi2,
  12. Hironori Harada2,
  13. Guliang Xia6,
  14. Yoshiaki Morita1,2,
  15. Ichiro Aramori1,2,
  16. Shuh Narumiya1, and
  17. Shimon Sakaguchi3,4,
  1. 1Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Konoe-cho Yoshida, Sakyo-ku, Kyoto, Kyoto 606-8501, Japan.
  2. 2Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  3. 3Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
  4. 4Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan.
  5. 5Department of Frontier Research in Tumor Immunology, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
  6. 6Astellas Research Institute of America, Skokie, IL 60077, USA.
  1. Corresponding author. Email: snaru{at}mfour.med.kyoto-u.ac.jp (S.N.); shimon{at}ifrec.osaka-u.ac.jp (S.S.)
  • * These authors contributed equally to this work.

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