Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

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Science Immunology  18 Oct 2019:
Vol. 4, Issue 40, eaaw9159
DOI: 10.1126/sciimmunol.aaw9159

Interior tumor views

Previous studies indicate that a high frequency of intratumoral neutrophils is associated with a poor clinical prognosis. Si et al. used a variety of microscopy and imaging techniques to examine how intratumoral interactions between tumor-associated neutrophils (TANs) and tumor-infiltrating lymphocytes (TILs) can affect TIL function. They developed 2D and 3D multiparameter immunofluorescence imaging techniques to localize and define functional cell subsets, which were used to identify hotspots of TAN/TIL interactions within tumors. Some of these TANs had a polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) phenotype, and their physical association with TILs reduced antitumor functions of those TILs. This study identifies areas of MDSC activity in human tumors and provides a more detailed perspective of how intratumoral cell interactions influence cell function.

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