Research ArticleINNATE LYMPHOID CELLS

Circadian rhythm–dependent and circadian rhythm–independent impacts of the molecular clock on type 3 innate lymphoid cells

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Science Immunology  04 Oct 2019:
Vol. 4, Issue 40, eaay7501
DOI: 10.1126/sciimmunol.aay7501

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Keeping track of time

A number of bodily functions, from feeding to sleeping, are regulated by our circadian clocks. Teng et al. and Wang et al. report that expression of a number of genes in intestinal group 3 innate lymphoid cells (ILC3s) in mice is synchronized to the time of day. To probe the role of clock proteins in regulating ILC3 functions, the two groups studied mice lacking distinct clock proteins, BMAL1 and REV-ERBα. Both groups found that the loss of these clock proteins resulted in marked losses of intestinal ILC3s, but that these ILC3s produced higher levels of certain cytokines. How clock proteins fit within the larger network of transcription factors in regulating development and gene expression in ILC3s remains to be seen.

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