November 2019
Vol 4, Issue 41

About The Cover

Cover image expansion

ONLINE COVER How Measles Virus Erases Immune Memories. This month's cover features an archival photo of a boy receiving a measles vaccine in 1962. Measles virus infection is followed by an extended period of immunosuppression, but how this "immune amnesia" comes about has been poorly understood. A school-associated measles outbreak enabled Petrova et al. to sequence immunoglobulin genes from B cells in pre- and post-infection blood samples and assess how viral infection affected the clonal organization of naïve and memory B cell subsets. A Focus commentary by Wesemann discusses the findings of Petrova et al. and the complementary findings described in a companion manuscript (Mina et al.) published in Science. [CREDIT: CDC PUBLIC HEALTH IMAGE LIBRARY]