ReportsINFECTIOUS DISEASE

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

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Science Immunology  15 Nov 2019:
Vol. 4, Issue 41, eaav2026
DOI: 10.1126/sciimmunol.aav2026

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Putting mice on a keto diet

Our immune responses to infections are influenced by several extrinsic factors, including weather, social interactions, and diet. Here, Goldberg et al. report that feeding mice a high-fat, low-carbohydrate ketogenic diet confers protection in the context of lethal influenza infection. By characterizing the immune response in the lungs, the authors identified that ketogenic diet promoted the expansion of γδ T cells in the lung. Using mice lacking γδ T cells, the authors have established the functional importance of these cells in conferring protection. Their findings suggest that γδ T cells improve barrier function in the lungs by modifying differentiation and function of the airway epithelial cells.

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