Ketogenic diet activates protective γδ T cell responses against influenza virus infection

Emily L. Goldberg; Ryan D. Molony; Eriko Kudo; Sviatoslav Sidorov; Yong Kong; Vishwa Deep Dixit; Akiko Iwasaki

doi:10.1126/sciimmunol.aav2026

ReportsINFECTIOUS DISEASE

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

Emily L. Goldberg ¹,²,
View ORCID ProfileRyan D. Molony²,³,
Eriko Kudo²,
View ORCID ProfileSviatoslav Sidorov¹,
View ORCID ProfileYong Kong⁴,
View ORCID ProfileVishwa Deep Dixit ¹,²,⁵,* and
View ORCID ProfileAkiko Iwasaki ²,⁶,⁷,*

¹Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA.
²Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.
³Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USA.
⁴Department of Molecular Biophysics and Biochemistry, W.M. Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA.
⁵Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06519, USA.
⁶Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
⁷Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT, 06511, USA.

↵*Corresponding author. Email: vishwa.dixit{at}yale.edu (V.D.D.); akiko.iwasaki{at}yale.edu (A.I.).

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Science Immunology 15 Nov 2019:
Vol. 4, Issue 41, eaav2026
DOI: 10.1126/sciimmunol.aav2026

Emily L. Goldberg

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA.

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.

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Ryan D. Molony

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.

3Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USA.

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Eriko Kudo

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.

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Sviatoslav Sidorov

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA.

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Yong Kong

4Department of Molecular Biophysics and Biochemistry, W.M. Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA.

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Vishwa Deep Dixit

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA.

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.

5Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06519, USA.

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For correspondence: vishwa.dixit@yale.edu akiko.iwasaki@yale.edu

Akiko Iwasaki

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.

6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

7Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT, 06511, USA.

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For correspondence: vishwa.dixit@yale.edu akiko.iwasaki@yale.edu

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Ketogenic diet activates protective γδ T cell responses against influenza virus infection

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