Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells

Melissa S. F. Ng; Theodore L. Roth; Ventura F. Mendoza; Alexander Marson; Trevor D. Burt

doi:10.1126/sciimmunol.aav5947

Research ArticleT CELL DIFFERENTIATION

Helios enhances the preferential differentiation of human fetal CD4⁺ naïve T cells into regulatory T cells

View ORCID ProfileMelissa S. F. Ng ¹,²,
View ORCID ProfileTheodore L. Roth ¹,³,⁴,
Ventura F. Mendoza⁵,
View ORCID ProfileAlexander Marson ³,⁴,⁶,⁷,⁸,⁹,¹⁰ and
View ORCID ProfileTrevor D. Burt ⁵,¹¹,*,†

¹Biomedical Sciences Graduate Program, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
²Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore 138648, Singapore.
³Department of Microbiology and Immunology, UCSF, San Francisco, CA 94143, USA.
⁴Diabetes Center, UCSF, San Francisco, CA 94143, USA.
⁵Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA 94143, USA.
⁶Innovative Genomics Institute, University of California, Berkeley, CA 94720, USA.
⁷Department of Medicine, UCSF, San Francisco, CA 94143, USA.
⁸Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
⁹UCSF Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.
¹⁰Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
¹¹Department of Pediatrics, Division of Neonatology, UCSF, San Francisco, CA 94110, USA.

↵*Corresponding author. Email: trevor.burt{at}duke.edu

↵† Present address: Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC 27710, USA.

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Science Immunology 22 Nov 2019:
Vol. 4, Issue 41, eaav5947
DOI: 10.1126/sciimmunol.aav5947

Melissa S. F. Ng

1Biomedical Sciences Graduate Program, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.

2Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore 138648, Singapore.

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ORCID record for Melissa S. F. Ng

Theodore L. Roth

1Biomedical Sciences Graduate Program, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.

3Department of Microbiology and Immunology, UCSF, San Francisco, CA 94143, USA.

4Diabetes Center, UCSF, San Francisco, CA 94143, USA.

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ORCID record for Theodore L. Roth

Ventura F. Mendoza

5Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA 94143, USA.

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Alexander Marson

3Department of Microbiology and Immunology, UCSF, San Francisco, CA 94143, USA.

4Diabetes Center, UCSF, San Francisco, CA 94143, USA.

6Innovative Genomics Institute, University of California, Berkeley, CA 94720, USA.

7Department of Medicine, UCSF, San Francisco, CA 94143, USA.

8Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

9UCSF Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.

10Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.

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ORCID record for Alexander Marson

Trevor D. Burt

5Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA 94143, USA.

11Department of Pediatrics, Division of Neonatology, UCSF, San Francisco, CA 94110, USA.

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ORCID record for Trevor D. Burt
For correspondence: trevor.burt@duke.edu

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Helios enhances the preferential differentiation of human fetal CD4⁺ naïve T cells into regulatory T cells

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