Research ArticleT CELLS

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

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Science Immunology  15 Nov 2019:
Vol. 4, Issue 41, eaaw0402
DOI: 10.1126/sciimmunol.aaw0402

Article Information

vol. 4 no. 41

Published By: 
  • Received November 20, 2018
  • Revision received May 9, 2019
  • Accepted October 18, 2019
  • .

Author Information

  1. Huimeng Wang1,2,
  2. Lars Kjer-Nielsen1,
  3. Mai Shi1,3,
  4. Criselle D’Souza1,4,
  5. Troi J. Pediongco1,
  6. Hanwei Cao1,
  7. Lyudmila Kostenko1,
  8. Xin Yi Lim1,
  9. Sidonia B. G. Eckle1,
  10. Bronwyn S. Meehan1,
  11. Tianyuan Zhu1,3,
  12. Bingjie Wang1,
  13. Zhe Zhao1,
  14. Jeffrey Y. W. Mak5,6,
  15. David P. Fairlie5,6,
  16. Michele W. L. Teng7,
  17. Jamie Rossjohn8,9,10,
  18. Di Yu11,
  19. Barbara Fazekas de St Groth12,
  20. George Lovrecz13,
  21. Louis Lu13,
  22. James McCluskey1,
  23. Richard A. Strugnell1,*,,
  24. Alexandra J. Corbett1,*, and
  25. Zhenjun Chen1,*,
  1. 1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  2. 2State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
  3. 3School of Medicine, Tsinghua University, Beijing, China.
  4. 4Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.
  5. 5Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  6. 6Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
  7. 7QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  8. 8Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  9. 9Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
  10. 10Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.
  11. 11John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601 Australia.
  12. 12Discipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
  13. 13Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.
  1. Corresponding author. Email: zhenjun{at} (Z.C.); corbetta{at} (A.J.C.); rastru{at} (R.A.S.)
  • * These authors contributed equally to this work.


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