Research ArticleT CELLS
IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection
- View ORCID ProfileHuimeng Wang1,2,
- View ORCID ProfileLars Kjer-Nielsen1,
- View ORCID ProfileMai Shi1,3,
- View ORCID ProfileCriselle D’Souza1,4,
- Troi J. Pediongco1,
- Hanwei Cao1,
- Lyudmila Kostenko1,
- View ORCID ProfileXin Yi Lim1,
- Sidonia B. G. Eckle1,
- View ORCID ProfileBronwyn S. Meehan1,
- Tianyuan Zhu1,3,
- Bingjie Wang1,
- View ORCID ProfileZhe Zhao1,
- View ORCID ProfileJeffrey Y. W. Mak5,6,
- View ORCID ProfileDavid P. Fairlie5,6,
- View ORCID ProfileMichele W. L. Teng7,
- View ORCID ProfileJamie Rossjohn8,9,10,
- View ORCID ProfileDi Yu11,
- View ORCID ProfileBarbara Fazekas de St Groth12,
- George Lovrecz13,
- Louis Lu13,
- View ORCID ProfileJames McCluskey1,
- View ORCID ProfileRichard A. Strugnell1,*,†,
- View ORCID ProfileAlexandra J. Corbett1,*,† and
- View ORCID ProfileZhenjun Chen1,*,†
- 1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
- 2State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
- 3School of Medicine, Tsinghua University, Beijing, China.
- 4Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.
- 5Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
- 6Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
- 7QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
- 8Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
- 9Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
- 10Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.
- 11John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601 Australia.
- 12Discipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
- 13Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.
- ↵†Corresponding author. Email: zhenjun{at}unimelb.edu.au (Z.C.); corbetta{at}unimelb.edu.au (A.J.C.); rastru{at}unimelb.edu.au (R.A.S.)
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Immunology 15 Nov 2019:
Vol. 4, Issue 41, eaaw0402
DOI: 10.1126/sciimmunol.aaw0402
Vol. 4, Issue 41, eaaw0402
DOI: 10.1126/sciimmunol.aaw0402
Huimeng Wang
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
2State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
Lars Kjer-Nielsen
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Mai Shi
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
3School of Medicine, Tsinghua University, Beijing, China.
Criselle D’Souza
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
4Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.
Troi J. Pediongco
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Hanwei Cao
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Lyudmila Kostenko
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Xin Yi Lim
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Sidonia B. G. Eckle
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Bronwyn S. Meehan
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Tianyuan Zhu
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
3School of Medicine, Tsinghua University, Beijing, China.
Bingjie Wang
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Zhe Zhao
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Jeffrey Y. W. Mak
5Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
6Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
David P. Fairlie
5Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
6Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
Michele W. L. Teng
7QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Jamie Rossjohn
8Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
9Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
10Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.
Di Yu
11John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601 Australia.
Barbara Fazekas de St Groth
12Discipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
George Lovrecz
13Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.
Louis Lu
13Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.
James McCluskey
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Richard A. Strugnell
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Alexandra J. Corbett
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Zhenjun Chen
1Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.