Research ArticleTUMOR IMMUNOLOGY

VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers

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Science Immunology  08 Nov 2019:
Vol. 4, Issue 41, eaay0555
DOI: 10.1126/sciimmunol.aay0555

Article Information

vol. 4 no. 41

PubMed: 
Published By: 
History: 
  • Received May 16, 2019
  • Accepted October 3, 2019
  • .

Author Information

  1. Chang Gon Kim1,*,
  2. Mi Jang2,*,
  3. Youngun Kim1,
  4. Galam Leem1,
  5. Kyung Hwan Kim1,
  6. Hoyoung Lee1,
  7. Tae-Shin Kim1,
  8. Seong Jin Choi1,
  9. Hyung-Don Kim1,
  10. Ji Won Han1,
  11. Minsuk Kwon1,
  12. Jong Hoon Kim1,
  13. Andrew J. Lee3,
  14. Su Kyung Nam3,
  15. Seok-Joo Bae1,
  16. Sat Byol Lee4,
  17. Sang Joon Shin5,
  18. Sung Ho Park6,
  19. Joong Bae Ahn5,
  20. Inkyung Jung3,
  21. Kang Young Lee4,
  22. Su-Hyung Park1,
  23. Hoguen Kim2,,
  24. Byung Soh Min4, and
  25. Eui-Cheol Shin1,
  1. 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
  2. 2Department of Pathology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
  3. 3Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
  4. 4Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
  5. 5Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
  6. 6School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
  1. Corresponding author. Email: ecshin{at}kaist.ac.kr (E.-C.S.); bsmin{at}yuhs.ac (B.S.M.); hkyonsei{at}yuhs.ac (H.K.)
  • * These authors contributed equally to this work.

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