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Research ArticleTUMOR IMMUNOLOGY
VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers
- Chang Gon Kim1,*,
- Mi Jang2,*,
- Youngun Kim1,
- Galam Leem1,
- Kyung Hwan Kim1,
- Hoyoung Lee1,
- Tae-Shin Kim1,
- Seong Jin Choi1,
- Hyung-Don Kim1,
- Ji Won Han1,
- Minsuk Kwon1,
- Jong Hoon Kim1,
- Andrew J. Lee3,
- Su Kyung Nam3,
- Seok-Joo Bae1,
- Sat Byol Lee4,
- Sang Joon Shin5,
- Sung Ho Park6,
- Joong Bae Ahn5,
- Inkyung Jung3,
- Kang Young Lee4,
- Su-Hyung Park1,
- Hoguen Kim2,†,
- Byung Soh Min4,† and
- Eui-Cheol Shin1,†
- 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
- 2Department of Pathology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
- 3Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
- 4Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
- 5Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
- 6School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
- ↵†Corresponding author. Email: ecshin{at}kaist.ac.kr (E.-C.S.); bsmin{at}yuhs.ac (B.S.M.); hkyonsei{at}yuhs.ac (H.K.)
↵* These authors contributed equally to this work.
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Science Immunology 08 Nov 2019:
Vol. 4, Issue 41, eaay0555
DOI: 10.1126/sciimmunol.aay0555
Vol. 4, Issue 41, eaay0555
DOI: 10.1126/sciimmunol.aay0555
Chang Gon Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Mi Jang
Department of Pathology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Youngun Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Galam Leem
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Kyung Hwan Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Hoyoung Lee
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Tae-Shin Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Seong Jin Choi
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Hyung-Don Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Ji Won Han
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Minsuk Kwon
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Jong Hoon Kim
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Andrew J. Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Su Kyung Nam
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Seok-Joo Bae
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Sat Byol Lee
Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Sang Joon Shin
Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Sung Ho Park
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Joong Bae Ahn
Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Inkyung Jung
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Kang Young Lee
Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Su-Hyung Park
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Hoguen Kim
Department of Pathology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Byung Soh Min
Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03772, Republic of Korea.
Eui-Cheol Shin
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
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