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A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

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Science Immunology  22 Nov 2019:
Vol. 4, Issue 41, eaay6039
DOI: 10.1126/sciimmunol.aay6039

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Charting MAIT cell development

Mucosal-associated invariant T (MAIT) cells are a distinct subset of T cells that recognize vitamin B metabolites presented by MHC class I–related protein (MR1). Here, using bulk and single-cell RNA- seq and flow cytometric analysis, Koay et al. have characterized the development of murine and human MAIT cells. In addition to providing us a clearer picture of MAIT cell development in the thymus, their studies have uncovered several molecules that play key roles in regulating this process. Using knockout mouse strains, they have confirmed the functions some of these molecules, including SAP (SLAM adaptor protein), SATB1, CXCR6, and CCR7 in regulating MAIT cell development.

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