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A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

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Science Immunology  22 Nov 2019:
Vol. 4, Issue 41, eaay6039
DOI: 10.1126/sciimmunol.aay6039

Article Information

vol. 4 no. 41

PubMed: 
Published By: 
History: 
  • Received July 2, 2019
  • Accepted October 15, 2019
  • .

Author Information

  1. H.-F. Koay1,2,
  2. S. Su3,4,
  3. D. Amann-Zalcenstein4,5,6,
  4. S. R. Daley7,*,
  5. I. Comerford8,
  6. L. Miosge7,
  7. C. E. Whyte8,
  8. I. E. Konstantinov9,10,11,
  9. Y. d’Udekem9,10,11,
  10. T. Baldwin4,6,12,
  11. P. F. Hickey4,
  12. S. P. Berzins1,13,14,
  13. J. Y. W. Mak15,16,
  14. Y. Sontani7,
  15. C. M. Roots7,
  16. T. Sidwell1,
  17. A. Kallies1,
  18. Z. Chen1,
  19. S. Nüssing1,
  20. K. Kedzierska1,
  21. L. K. Mackay1,2,
  22. S. R. McColl8,
  23. E. K. Deenick17,18,
  24. D. P. Fairlie15,16,
  25. J. McCluskey1,
  26. C. C. Goodnow17,19,
  27. M. E. Ritchie3,6,
  28. G. T. Belz5,6,
  29. S. H. Naik4,5,6,
  30. D. G. Pellicci1,2,11, and
  31. D. I. Godfrey1,2,
  1. 1Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  2. 2Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Melbourne, Victoria 3000, Australia.
  3. 3Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  4. 4Single Cell Open Research Endeavour (SCORE), Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  5. 5Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  6. 6Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia.
  7. 7Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
  8. 8Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia.
  9. 9Royal Children’s Hospital, Flemington Road, Parkville, Victoria 3052, Australia.
  10. 10Melbourne Children’s Centre for Cardiovascular Genomics and Regenerative Medicine, Murdoch Children’s Research Institute, Victoria 3052, Australia.
  11. 11Murdoch Children’s Research Institute, Victoria 3052, Australia.
  12. 12Blood Cells and Blood Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  13. 13Federation University Australia, Ballarat, Victoria 3350, Australia.
  14. 14Fiona Elsey Cancer Research Institute, Ballarat, Victoria 3350, Australia.
  15. 15Division of Chemistry and Structural Biology, and Centre for Inflammation and Disease Research, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
  16. 16Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland 4072, Australia.
  17. 17Garvan Institute of Medical Research, Sydney, Australia.
  18. 18St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia.
  19. 19UNSW Cellular Genomics Futures Institute, UNSW, Sydney, Australia.
  1. Corresponding author. Email: godfrey{at}unimelb.edu.au (D.I.G.); dan.pellicci{at}mcri.edu.au (D.G.P.)
  • * Present address: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.

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