Contents
December 2019
Vol 4, Issue 42
Vol 4, Issue 42
Focus
- IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine
IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article by Takashima et al.).
Research Articles
- Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity
Early-life LTβR signaling programs the mesenteric lymph node stromal cell environment, optimizing gut IgA responses in the adult mouse.
- Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2
STAT2R148W impairs an essential regulatory function of STAT2, revealing the damage wreaked by excessive IFNα/β activity.
- GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment
GCN2 is a key driver of Mϕ and MDSC polarization in the tumor microenvironment causing T cell exhaustion.
- T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage
T cell–derived interferon-γ can directly target intestinal stem cells to induce their apoptosis in a JAK/STAT-dependent manner (see the related Focus by Kretzschmar and Clevers).
- Clec10a regulates mite-induced dermatitis
Clec10a on skin macrophages recognizes a mucin-like molecule of house dust mite and suppresses mite-induced dermatitis.
Editors' Choice
- It takes 2 TOXes to Tfh Tango
TOX and TOX2 promote T follicular helper cell development through transcriptional changes and epigenetic remodeling.
- Fast-acting autoantibodies muscle in on encephalitis
Autoantibodies that recognize the glycine receptor mediate pathology by directly interrupting glycinergic neurotransmission that manifests as a disorder characterized by muscle stiffness and spasms.
About The Cover
ONLINE COVER Intestinal Stem Cells in the Crosshairs of T Cell–Derived IFN-γ. Featured on the cover is a cross-section of mouse jejunum showing "lineage ribbons" of red epithelial cells derived from intestinal stem cells (ISCs) found in the crypt. Takashima et al. found that T cell–mediated damage to the intestinal epithelium in a mouse model of graft-versus-host disease results from the direct toxic effect of IFN-γ on ISCs rather than the adjacent Paneth cells that provide a niche for ISCs. A Focus commentary by Kretzschmar and Clevers discusses the findings of Takashima et al. [CREDIT: S. TAKASHIMA ET AL./SCIENCE IMMUNOLOGY]
